Dr. Samaan is a pediatric endocrinologist at MCH and Associate professor at the Department of Pediatrics, McMaster University. He did his pediatric endocrine training in Ireland and at Sick Kids Toronto. Dr. Fleming is Director of the Neuro-oncology clinic, the co-founder of the McMaster Pediatric Brain Tumour Study Group, and runs several research trials for children with brain tumours. He is also the Neoplasia planner for UGME, a design tutor in the iBiomed engineering program, and the Program Director for sub-specialty training in Pediatric Hematology and Oncology. In this portion of Grand Rounds, Drs. Samaan and Fleming share their work on elucidating the endometabolic profile of survivors of childhood brain tumors and share their vision of what makes a successful collaboration.